LL-37 5mg (CAP-18)

LL-37 5mg (CAP-18) is a premium-grade, synthetic 37-amino-acid cathelicidin-derived amphipathic alpha-helical peptide manufactured to ≥98% purity. Available exclusively for in vitro and laboratory research applications, this lyophilized formulation serves as a foundational biochemical tool for investigating innate immunity response, membrane permeabilization kinetics, and cellular chemotaxis pathways. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

LL-37, biochemically recognized as the functional C-terminal domain of the human Cathelicidin Antimicrobial Peptide (CAP-18), is the sole member of the cathelicidin family endogenously expressed in humans. It occupies a critical position in mucosal immunology, wound-response modeling, and systemic host-defense research. The Peptide Store supplies this immunomodulatory research agent as a precision-formulated 5mg lyophilized matrix, offering immunology, microbiology, and regenerative medicine laboratories a highly stable, ultra-pure baseline reagent engineered to explore cell-autonomous defenses, lipopolysaccharide (LPS) neutralization, and receptor-mediated signaling cascades.

Peptide Structure & Amino Acid Sequence

LL-37 is a 37-residue linear peptide with the following confirmed amino acid sequence:

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

This sequence adopts a characteristic amphipathic alpha-helical conformation upon interaction with anionic membranes, a structural property central to its research utility in membrane permeabilization and host-defense studies. The peptide’s cationic charge distribution and hydrophobic moment make it a uniquely valuable model compound for structural biology and biophysics research teams.

Chemical & Physical Characteristics

• Peptide Length: 37 amino acids
• Molecular Formula: C₂₀₅H₃₄₀N₆₀O₅₃
• Molecular Weight: Approximately 4,493.3 Da
• Net Charge: +6 at physiological pH
• Secondary Structure: Amphipathic alpha-helix (membrane-induced)
• Physical Form: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffers and dilute acetic acid solutions (for research purposes only)

Purity & Analytical Verification (HPLC & MS)

Every batch of LL-37 5mg supplied by The Peptide Store is analytically verified to a minimum purity threshold of ≥98% using reverse-phase high-performance liquid chromatography (RP-HPLC). Molecular identity is independently confirmed via mass spectrometry (MS), ensuring that the observed molecular ion is consistent with the theoretical mass of the target sequence. These dual-verification protocols provide researchers with the confidence necessary for reproducible, publication-quality experimental outcomes.

Quality Control & Lyophilization Integrity

Lyophilization is employed as the preservation method of choice for LL-37 to maximize long-term structural integrity and biological activity in research settings. The freeze-drying process removes residual moisture to levels below accepted thresholds, preventing hydrolytic degradation and aggregation during storage and transit. Each production lot undergoes rigorous quality control review, including visual inspection, moisture content assessment, and chromatographic profiling, before release for sale. Certificates of Analysis (CoA) are available upon request for every lot number.

Safety, Handling & Laboratory Precautions

LL-37 is supplied strictly as a research reagent and must be handled exclusively by trained laboratory professionals operating under appropriate institutional biosafety guidelines. Standard laboratory personal protective equipment (PPE) — including nitrile gloves, safety eyewear, and a laboratory coat — should be worn at all times when handling this compound. Researchers should consult the relevant Safety Data Sheet (SDS) prior to use. This peptide is not approved for any human or animal administration under any circumstances.

Reconstitution, Packaging & Storage

LL-37 5mg is packaged in sterile, sealed vials suitable for laboratory research environments. For optimal stability, the lyophilized product should be stored at -20°C upon receipt and kept away from light, humidity, and repeated freeze-thaw cycles. Reconstitution guidance provided by The Peptide Store is intended solely for preparation of research stock solutions and must not be interpreted as instructions for any consumptive or clinical application. When handled and stored correctly, lyophilized LL-37 retains its structural integrity for extended research periods.

Intended Research Use & Market Positioning

LL-37 5mg (CAP-18) is positioned as a premier research-grade reagent for academic institutions, government research agencies, and licensed private laboratories engaged in the following areas of scientific investigation:

• Innate immunity and host-defense mechanism research
• Antimicrobial membrane interaction and permeabilization studies
• LPS neutralization and endotoxin-binding assays
• Cellular chemotaxis and immunomodulation pathway analysis
• Wound-healing and regenerative biology models (in vitro)
• Structural biology and alpha-helix conformation studies

Ordering, Availability & Fulfillment

The Peptide Store offers LL-37 5mg (CAP-18) for sale online with streamlined ordering, competitive best-price positioning, and reliable international fulfillment. Researchers can order now through our secure eCommerce platform and benefit from fast dispatch, discreet packaging, and full lot traceability. Bulk quantities and institutional procurement inquiries are welcomed — contact our team directly for custom volume pricing and availability.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. LL-37 5mg (CAP-18) is sold exclusively as a laboratory research reagent. The Peptide Store makes no representations regarding the suitability of this compound for therapeutic, prophylactic, or diagnostic purposes. All purchasers are solely responsible for ensuring compliance with applicable local, national, and international regulations governing the procurement, handling, and use of synthetic research peptides. This product must not be administered to humans or animals under any circumstances.